購(gòu)物車
幫助
021-54845833/15800441009
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Full name: |
melanogenesis associated transcription factor |
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Synonyms: |
MI; WS2; CMM8; WS2A; COMMAD; bHLHe32 |
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Swissprot: |
O75030 |
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Gene Accession: |
BC026961 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
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