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中文名稱：兔抗DLAT多克隆抗體

英文名稱： Anti-DLAT rabbit polyclonal antibody

別名： DLTA; PDCE2; PDC-E2

相關(guān)類別： 一抗

儲(chǔ) 存： 冷凍（-20℃）

宿主： Rabbit

抗原： DLAT

反應(yīng)種屬： Human, Mouse, Rat

標(biāo) 記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Applications:

ELISA, WB, IHC

Name of antibody:

DLAT

Immunogen:

Fusion protein of human DLAT

Full name:

dihydrolipoamide S-acetyltransferase

Synonyms：

DLTA; PDCE2; PDC-E2

SwissProt:

P10515

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer and Human prostate cancer

IHC Recommend dilution:

30-150

WB Predicted band size:

69 kDa

WB Positive control:

A431, hepg2 and lncap cell

WB Recommended dilution:

500-2000

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ELISA試劑盒

PCR試劑盒

生化試劑盒

細(xì)胞系

細(xì)胞庫

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

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兔抗DLAT多克隆抗體

Background:	This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.
Applications:	ELISA, WB, IHC
Name of antibody:	DLAT
Immunogen:	Fusion protein of human DLAT
Full name:	dihydrolipoamide S-acetyltransferase
Synonyms：	DLTA; PDCE2; PDC-E2
SwissProt:	P10515
ELISA Recommended dilution:	2000-5000
IHC positive control:	Human breast cancer and Human prostate cancer
IHC Recommend dilution:	30-150
WB Predicted band size:	69 kDa
WB Positive control:	A431, hepg2 and lncap cell
WB Recommended dilution:	500-2000