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中文名稱：兔抗ECD多克隆抗體

英文名稱： Anti-ECD rabbit polyclonal antibody

別名： ecdysoneless cell cycle regulator; GCR2; SGT1; HSGT1

相關(guān)類別： 一抗

儲(chǔ) 存： 冷凍（-20℃）

宿主： Rabbit

抗原： ECD

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

Applications:

ELISA, WB, IHC

Name of antibody:

ECD

Immunogen:

Fusion protein of human ECD

Full name:

ecdysoneless cell cycle regulator

Synonyms:

GCR2; SGT1; HSGT1

SwissProt:

O95905

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

73 kDa

WB Positive control:

Jurkat and PC3 cell lysates

WB Recommended dilution:

200-1000

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細(xì)胞系

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完全培養(yǎng)基

原代細(xì)胞

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菌株

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兔抗ECD多克隆抗體

Background:	Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Applications:	ELISA, WB, IHC
Name of antibody:	ECD
Immunogen:	Fusion protein of human ECD
Full name:	ecdysoneless cell cycle regulator
Synonyms:	GCR2; SGT1; HSGT1
SwissProt:	O95905
ELISA Recommended dilution:	5000-10000
IHC positive control:	Human cervical cancer and Human thyroid cancer
IHC Recommend dilution:	25-100
WB Predicted band size:	73 kDa
WB Positive control:	Jurkat and PC3 cell lysates
WB Recommended dilution:	200-1000