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021-54845833/15800441009
中文名稱： 兔抗MLKL多克隆抗體
英文名稱： Anti-MLKL rabbit polyclonal antibody
別 名： mixed lineage kinase domain like pseudokinase; hMLKL
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： MLKL
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
MLKL |
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Immunogen: |
Fusion protein of human MLKL |
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Full name: |
mixed lineage kinase domain like pseudokinase |
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Synonyms: |
hMLKL |
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SwissProt: |
Q8NB16 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer and Human tonsil |
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IHC Recommend dilution: |
50-300 |
