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  • NR1I3 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW19407
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:60
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中文名稱: NR1I3 抗原(重組蛋白)

英文名稱: NR1I3 Antigen (Recombinant Protein)

別     名:  nuclear receptor subfamily 1 group I member 3; CAR; CAR1; MB67

儲(chǔ)     存:  冷凍(-20℃)

相關(guān)類別: 抗原

概     述

Fusion protein corresponding to a region derived from 153-352 amino acids of human NR1I3

技術(shù)規(guī)格

Full name:

nuclear receptor subfamily 1 group I member 3

Synonyms:

CAR; CAR1; MB67

Swissprot:

Q14994

Gene Accession:

BC069626

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.



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