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中文名稱(chēng)：兔抗ERN2多克隆抗體

英文名稱(chēng)： Anti-ERN2 rabbit polyclonal antibody

別名： IRE1b; IRE1-BETA

相關(guān)類(lèi)別： 一抗

儲(chǔ) 存： 冷凍（-20℃）

宿主： Rabbit

抗原： ERN2

反應(yīng)種屬： Human

標(biāo) 記物： Unconjugate

克隆類(lèi)型： rabbit polyclonal

技術(shù)規(guī)格

Background:

The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Applications:

ELISA, IHC

Name of antibody:

ERN2

Immunogen:

Synthetic peptide of human ERN2

Full name:

endoplasmic reticulum to nucleus signaling 2

Synonyms：

IRE1b; IRE1-BETA

SwissProt:

Q76MJ5

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human gastric cancer

IHC Recommend dilution:

50-200

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021-54845833/15800441009

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PCR試劑盒

生化試劑盒

細(xì)胞系

細(xì)胞庫(kù)

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完全培養(yǎng)基

原代細(xì)胞

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菌株

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病理染色液

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兔抗ERN2多克隆抗體

Background:	The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Applications:	ELISA, IHC
Name of antibody:	ERN2
Immunogen:	Synthetic peptide of human ERN2
Full name:	endoplasmic reticulum to nucleus signaling 2
Synonyms：	IRE1b; IRE1-BETA
SwissProt:	Q76MJ5
ELISA Recommended dilution:	2000-5000
IHC positive control:	Human liver cancer and Human gastric cancer
IHC Recommend dilution:	50-200