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中文名稱(chēng)：兔抗FEN1多克隆抗體

英文名稱(chēng)： Anti-FEN1 rabbit polyclonal antibody

別名： FEN1; FEN-1; MF1; RAD2

相關(guān)類(lèi)別：一抗

儲(chǔ) 存： 冷凍（-20℃）避光

宿主： Rabbit

抗原： FEN1

反應(yīng)種屬： Human, Mouse, Rat

標(biāo) 記物： Unconjugate

克隆類(lèi)型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.

Applications:

WB

Name of antibody:

FEN1

Immunogen:

Fusion protein of human FEN1

Full name:

flap structure-specific endonuclease 1

Synonyms：

FEN1; FEN-1; MF1; RAD2

SwissProt:

P39748

WB Predicted band size:

43 kDa

WB Positive control:

NIH3T3, HeLa, Jurkat and Y79 cells, spleen and testis tissue

WB Recommended dilution:

500-2000

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兔抗FEN1多克隆抗體

Background:	Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.
Applications:	WB
Name of antibody:	FEN1
Immunogen:	Fusion protein of human FEN1
Full name:	flap structure-specific endonuclease 1
Synonyms：	FEN1; FEN-1; MF1; RAD2
SwissProt:	P39748
WB Predicted band size:	43 kDa
WB Positive control:	NIH3T3, HeLa, Jurkat and Y79 cells, spleen and testis tissue
WB Recommended dilution:	500-2000