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  • 兔抗PSEN1多克隆抗體

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW22009
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:80
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中文名稱:  兔抗PSEN1多克隆抗體


英文名稱:  Anti-PSEN1 rabbit polyclonal antibody


別       名:  presenilin 1 AD3; FAD; PS1; PS-1; S182


相關(guān)類(lèi)別:  一抗


抗       原:  PSEN1


儲(chǔ)       存:  冷凍(-20℃)


宿      主:  Rabbit


反應(yīng)種屬:  Human, Mouse


標(biāo)  記  物:  Unconjugate


克隆類(lèi)型:  rabbit polyclonal


技術(shù)規(guī)格

Background:

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

PSEN1

Immunogen:

Synthetic peptide of human PSEN1

Full name:

presenilin 1

Synonyms:

AD3; FAD; PS1; PS-1; S182

SwissProt:

P49768

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer;

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

Human kidney tissue,RAW264.7 cell,Mouse kidney tissue,Mouse liver tissue lysates

WB Recommended dilution:

200-1000







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