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    • 品牌 : 通蔚生物
    • 目錄號 : TW4672
    • 應用 : 僅用于科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:35
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中文名稱:兔抗CCN4多克隆抗體

英文名稱:
Anti-CCN4 rabbit polyclonal antibody

別      名: cellular communication network factor 4; WISP1; WI

相關(guān)類別: 一抗

儲      存:
冷凍(-20℃)

宿      主:
Rabbit

抗      原:
CCN4

反應種屬:
Human, Mouse, Rat

標 記 物: Unconjugate

克隆類型:
rabbit polyclonal

技術(shù)規(guī)格

Background:

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

Applications:

ELISA, IHC

Name of antibody:

CCN4

Immunogen:

Synthetic peptide of human CCN4

Full name:

cellular communication network factor 4

Synonyms:

WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1

SwissProt:

O95388

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

25-100



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