購物車
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021-54845833/15800441009
別 名： CSBP; FLJ41122; HNRPK; TUNP
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： HNRNPK
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
Background:
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) belongs to a family of RNA binding multiprotein complexes (hnRNP proteins) that facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm. hnRNP K contains three unique structural motifs termed KH domains that bind poly(C) DNA and RNA sequences. Intricate architecture enables hnRNP K to facilitate mRNA biosynthesis, transcriptional regulation, and signal transduction. Research studies have shown that cytoplasmic hnRNP K expression is increased in oral squamous cell carcinoma and pancreatic cancer, and may be a potential prognostic factor. hnRNP K coordinates with p53 to regulate its target gene transcription in response to DNA damage. Proteasome degradation of hnRNP K is mediated by E3 ligase MDM2. The interaction between hnRNP K and c-Src leads to hnRNP K phosphorylation, which allows for hnRNP K activation of silenced mRNA translation.
Applications:
WB
Name of antibody:
HNRNPK
Immunogen:
Fusion protein of human HNRNPK
Full name:
heterogeneous nuclear ribonucleoprotein K
Synonyms：
CSBP; FLJ41122; HNRPK; TUNP
SwissProt:
P61978
WB Predicted band size:
51 kDa
WB Positive control:
HeLa cells
WB Recommended dilution:
500-2000
技術(shù)規(guī)格
